Expression of VEGF and SOX2 in squamous cell lung cancer and prognosis effect
10.3969/j.issn.1006-5725.2017.23.008
- VernacularTitle:血管内皮生长因子和SOX2在肺鳞状细胞癌中的表达及其与预后的关系
- Author:
Lu ZHAO
1
;
Yongbo SONG
;
Yanling ZHANG
;
Xiaoming DU
;
Xuan PAN
Author Information
1. 皖北煤电集团总医院肿瘤一科
- Keywords:
squamous cell lung cancer;
vascular endothelial growth factor(VEGF);
sex-determining region Y-box 2(SOX2);
prognosis
- From:
The Journal of Practical Medicine
2017;33(23):3880-3885
- CountryChina
- Language:Chinese
-
Abstract:
Objective Preliminarily discussing the effects of VEGF and SOX2 on metastasis and progno-sis of squamous cell lung carcinoma(SCLC).Methods Using immunohistochemical method to detect 47 cases of pulmonary squamous cell carcinoma and 30 cases of para-carcinoma tissue in the expression of VEGF and SOX2, using statistical methods to analyze the expression of VEGF and SOX2 and the relationship between clinical parame-ters and its relationship with prognosis. Results The positive expression rates of VEGF,SOX2 in SCLC tissues were higher than adjacent normal tissues.There was a significant correlation between VEGF and SOX2 expression. VEGF expression was associated with lymph node metastases and TNM stage.SOX2 expression was associated with tumor differentiation and lymph node status.Survival analysis indicated that VEGF(+)/SOX2(+)patients had the worst prognosis.Furthermore,multivariate analysis suggested that tumor diameter and lymph node metastases were independent prognostic factors for SCLC. Conclusion The expression of VEGF was positively correlated with lymph node metastasis and clinical stage,the expression of SOX2 was positively correlated with tumor differentia-tion degree and lymph node metastasis,and high expression of VEGF and SOX2 may indicate lung squamous can-cer patients with poor prognosis.
