Clinical efficacy of sequential hemoperfusion combined with rhubarb for sequential treatment for patients with paraquat poisoning
10.3969/j.issn.1006-5725.2017.23.016
- VernacularTitle:持续血液灌流联合大黄为主组方序贯治疗百草枯中毒的临床疗效
- Author:
Weizhan WANG
1
;
Jing LI
;
Qingmian XIAO
;
Hongna QI
;
Baoyue ZHU
;
Wei LI
;
Guoying MA
;
Pu WANG
;
Lan WANG
Author Information
1. 河北医科大学哈励逊国际和平医院急救医学部
- Keywords:
acute paraquat poisoning;
continuous hemoperfusion;
traditional Chinese medicine;
treatment
- From:
The Journal of Practical Medicine
2017;33(23):3915-3918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of sequential hemoperfusion combined with rhu-barb as the main treatment for patients with acute paraquat poisoning(acute,paraquat,poisoning,APP). Meth-ods 16 moderate APP patients in our hospital were randomly divided into group A(hemoperfusion group,31 cas-es),group B(hemoperfusion combined with rhubarb as the main prescription group,40 cases)and group C(con-tinuous hemoperfusion combined with rhubarb as the main prescription group,45 cases),respectively.Levels of C-reactive protein(CRP),alanine aminotransferase(ALT),creatine kinase(CK-MB),creatinine(Cr),tumor ne-crosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-10(IL-10)were determined before treatment and at 5 d,7 d post-treatment. At 8 h,12 h and 24 h post-treatment,serum paraquat level was determined. Results After treatment,the total effective rate of group C(68.89%)was significantly higher than that of group A (35.48%),group B(52.5%),with significant differences among groups(χ2= 8.335,P=0.015). Levels of ALT,CK-MB,Cr,CRP,TNF-α,IL-6 and IL-10 were significantly increased at 5 d post-treatment in group A, but were significantly decreased at 7d post-treatment in group C,with significant differences among groups(P<0.05).The serum paraquat content in group B and C was lower than that in group A at 8 h post-treatment.The se-rum paraquat content was the lowest in group C at 12h post-treatment(P < 0.05). However,the serum paraquat content decreased significantly in each group at 24 h post-treatment,with no significant differences among three groups. Conclusions The early continuous hemoperfusion combined with rhubarb-based sequential treatment of APP can effectively reduce the fatality rate and improve prognosis of APP patients.
