Effect of the dose-dense temozolomide on glioblastoma:A network meta-analysis
10.3969/j.issn.1006-5725.2017.22.036
- VernacularTitle:高剂量替莫唑胺治疗在胶质母细胞瘤中应用的网状Meta分析
- Author:
Xiangqi SONG
1
;
Mei LI
;
Aijun FU
;
Jun ZHU
;
Jianmin LI
;
Zelin SUN
;
Tong CHEN
Author Information
1. 061000,河北省沧州市肃宁县人民医院神经外科
- Keywords:
glioblastoma;
temozolomide;
dose-dense;
network meta-analysis
- From:
The Journal of Practical Medicine
2017;33(23):3990-3994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the intervention effect of the dose-dense schemes of temozolomide on the newly diagnosed glioblastoma compared with the standard schemes. Methods The Pubmed,Cochrane,Em-base,CNKI,CBM,Wanfang,VIP databases were used for the retrievals on the intervention effect.The quality of included papers was assessed to extract network meta-analysis data with using the statistical software Stata 13.0. Results The treatment plans were ranked according to the intervention effect from the best to the worst as follows:the dose-dense,the early,the metronomic,the standard,the RT and post-RT adjuvant temozolomide. The most common adverse effects in hematotoxicity were neutropenia,leucopenia,lymphopenia,thrombocytopenia and ane-mia. Between the different temozolomide therapeutic regimens,there was no significant difference. Conclusion The intervention effect of the dose-dense schemes with temozolomide is better than the standard therapy. It also revealed that,the hematoxicity in the different temozolomide schemes is not significantly different.
