Effects of ovarian induction with Raloxifene versus Clomiphene Citrate on endometrial receptivity in mouse endometrium
10.3969/j.issn.1006-5725.2017.24.008
- VernacularTitle:两种口服促排卵药物对小鼠子宫内膜容受性影响的比较
- Author:
Yingjie XIAN
1
;
Cairong CHEN
;
Xiaoqing LIANG
;
Xiuqin ZHOU
;
Shigang WU
;
ia Qiux YAN
;
Xiaoying ZHAO
Author Information
1. 511500 广东省清远市,广州医科大学附属第六医院,清远市人民医院生殖医学中心
- Keywords:
raloxifene;
clomiphene citrate;
cycloxygenase-2;
lysophosphatidic acid receptor-3
- From:
The Journal of Practical Medicine
2017;33(24):4053-4056
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ovarian induction with raloxifene(RAL)versus clomi-phene citrate(CC)on the endometrial receptivity in mouse endometrium during perimplantation period. Methods 48 female Kun-ming mouse were randomly divided into four groups in equal number:RAL 240 mg group,RAL 180 mg group,CC group,natural conception group(NC),all treated with ovulation induction after drug administration.Successfully mated female mouse were killed,and uterus samples were collected for HE stain-ing and immunohistochemistry. Results HE staining showed that the endometrial morphology in the RAL 180 mg group and RAL 240 mg group and NC group were better than that of CC group.The expressions of COX-2 and LP-AR3 in the RAL 180 mg group and RAL 240 mg group were similar to NC group,without significant difference among the three groups(P > 0.05). But in the CC group,it was statistically significantly lower than other three groups(P<0.05),indicating ovarian induction with RAL did not decrease the expressions of COX-2 and LPAR3 in endometrium. Conclusion The mechanism of ovulation induction with RAL is similar to CC,but RAL has fewer adverse effects on the endometrial receptivity compared with CC.
