Establishment of reference range of serum thyroid hormone in women with different gestational age in Wu-han area
10.3969/j.issn.1006-5725.2017.24.015
- VernacularTitle:武汉地区不同妊娠期女性血清甲状腺激素参考范围的建立
- Author:
Wenqian CAI
1
;
Xijiang HU
;
Ting YAO
;
Qi CHEN
Author Information
1. 430016,华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)
- Keywords:
pregnancy;
thyroid hormones;
reference intervals
- From:
The Journal of Practical Medicine
2017;33(24):4082-4086
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the laboratory and geography-specific reference intervals for thyroid hormones during pregnancy and changes of serum thyroid hormone in Wuhan. Methods According to NACB guidelines,a total of 1 186 female including in or without pregnancy were recruited in our hospital randomly when they came to routine antenatal clinic. The 2.5 th and 97.5 th percentiles were calculated as the reference intervals for specialty of serum thyroid function including serum thyroid stimulating hormone(TSH),serum free three io-dine thyroid(FT3),serum free thyroxine(FT4)levels during each trimester by chemiluminescence.Results On comparing to non-pregnant women,the serum thyroid hormone in pregnant women had significant difference as the following:(1)FT3 concentrations showed decreased median centile throughout gestation step by step;(2)FT4 lev-els in second and third trimester had slightly decreased;(3)TSH levels had significant decreased in first and sec-ond trimeste and had no significant difference between the early pregnancy and middle pregnancy,and had recoved to the similar level of before pregnancy in middle pregnancy and late pregnancy.Compared with control group,the serum thyroid function levels of pregnant women had significant differences in trimesters. There were 5.84%, 19.09% and 28.91% of women in the first,second and third trimester,respectively,with serum TSH higher than the upper reference limit,or lower than the lower reference limit.Conclusions Serum thyroid function had signifi-cant correlations with pregnancy in Wuhan area. To establish pregnancy-specific thyroid function reference inter-vals of local area can reduce underdiagnosis effectively in thyroid gland related diseases.
