Value analysis of CA19-9,s-ULBP2 and Dkk1 in the diagnosis of pancreatic cancer
10.3969/j.issn.1006-5725.2017.24.016
- VernacularTitle:CA19-9、s-ULBP2、Dkk1联合诊断胰腺癌的价值
- Author:
Dapeng CUI
1
;
Yingchun ZHANG
;
Jingjing LIAN
;
Bo LIU
;
Fei LIU
;
Lei HAN
;
Yujia WANG
;
Shuquan GAO
Author Information
1. 河北北方学院附属第一医院肝胆外科
- Keywords:
pancreatic cancer;
carbohydrate antigen 199;
secretory protein;
ULBP
- From:
The Journal of Practical Medicine
2017;33(24):4086-4089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of CA19-9,s-ULBP2 and Dkk1 in the diagnosis of pancreatic cancer and the correlation. Methods From January 2016 to May 2017,56 patients with pancreatic cancer in our hospital were selected,45 healthy subjectsand 33 patients with benign pancreatic diseaseswere enrolled in this study.The differences of serum CA19-9,Dkk1 and s-ULBP2 expression and their relationship with clinicopatholog-ical parameters were compared between the three groups. The diagnostic value of CA19-9,s-ULBP2,Dkk1 and joint detection was analyzed.Results The serum levels of CA19-9,s-ULBP2 and Dkk1 in patients with pancreat-ic cancer were significantly higher than those in the benign pancreatic disease group and the healthy control group (P<0.05).CA19-9 and s-ULBP2 are related to TNM staging and histological differentiation,and CA19-9 is also related to tumor location.Joint test was higher than any of the individual indicators.Conclusion CA19-9,s-ULBP2 and Dkk1 are closely related to pancreatic cancer,and the combined detection of the three can improve the diag-nostic accuracy of pancreatic cancer.
