The Effect of Hypertonic Saline and Mannitol against Edema Formation after Cryogenic Brain Injury in Rats.
10.4097/kjae.2000.38.1.152
- Author:
Seong Wan BAIK
1
;
Kyoo Sub CHUNG
;
Inn Se KIM
;
Hae Kyu KIM
;
Sang Wook SHIN
;
Kyu Wan KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Animal: rats;
Brain: cryogenic;
edema;
injury;
Fluids: hypertonic saline;
mannitol
- MeSH:
Animals;
Blood-Brain Barrier;
Brain Edema;
Brain Injuries*;
Brain*;
Edema*;
Mannitol*;
Rats*
- From:Korean Journal of Anesthesiology
2000;38(1):152-157
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: After experimental cryogenic cerebral injury, severe focal brain contusion develops due to blood-brain barrier breakdown and vasogenic cerebral edema formation. This study has been conducted to find out the effects of hypertonic saline against cryogenic brain edema in rats. METHODS: Thirty rats of either sex weighing 250 to 300 g underwent a 60 seconds of cryogenic brain injury. All rats were randomly divided into one of three groups; control group (n = 10), 7.5% saline group (n = 10), and 10% mannitol group (n = 10). The water contents were measured 60 minutes after cryogenic injury by using the dry-weight method. RESULTS: The water contents in the 7.5% saline and 10% mannitol groups were significantly decreased compared with the control group. The levels of edema in the 7.5% saline and 10% mannitol groups were also significantly decreased compared with the control group. Although it appeared as if that 10% mannitol might decrease edema formation more than 7.5% saline, there were no statistical differences between the 7.5% saline and 10% mannitol groups. CONCLUSIONS: Hypertonic saline (7.5%) may be as effective agent to reduce edema formation after brain trauma to the same degree as mannitol.
