Effect of Therapy of Tonifying Kidney,Activating Bone-marrow,and Unblocking Collaterals on Thromboelastogram Platelet Maximum Amplitude Value of Patients with Chronic Aplastic Anemia
10.13359/j.cnki.gzxbtcm.2018.01.005
- VernacularTitle:补肾活髓通络法对慢性再生障碍性贫血患者血栓弹力图Ma值的影响
- Author:
Hua Jing WANG
1
;
Hua Yuan GAO
;
Wen Shi GU
;
Qing Shu WANG
Author Information
1. 潍坊医学院
- Keywords:
chronic aplastic anemia;
therapy of tonifying kidney;
activating bone-marrow;
and unblocking collaterals;
thromboelastogram platelet maximum amplitude (Ma)value;
traditional Chinese drug therapy
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2018;35(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of therapy of tonifying kidney,activating bone-marrow, and unblocking collaterals for patients with chronic aplastic anemia (CAA), and to investigate its effect on thromboelastogram platelet maximum amplitude (Ma) value for exlporing its therapeutic mechanism. Methods Sixty CAA patients were randomized into trial group and control group, 30 cases in each group. The control group was given oral use of Stanozolol and Cyclosporin A, and the trial group was orally given the recipe with the actions of tonifying kidney,activating bone-marrow,and unblocking collaterals,which is mainly composed of Radix Rehmanniae,Radix Rehmanniae Preparata,Caulis Spatholobi,Semen Cuscutae,Fructus Lycii,Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Herba Ecliptae, Pheretima, and Semen Strychni Preparata. The clinical efficacy was evaluated after treatment,and peripheral hemogram and thromboelastogram Ma value of the two groups were compared before and after treatment. Results (1)The trial group had better western medicine therapeutic effect and traditional Chinese medicine (TCM)syndrome therapeutic effect than the control group, the difference being signficant (P < 0.01).(2) After treatment, TCM syndrome scores, parameters of blood routine test,thromboelastogram Ma value of the two groups were improved compared with those before treatment (P < 0.05 or P < 0.01),and the improvement in the trial group was superior to that in the control group (P <0.05). Conclusion Therapy of tonifying kidney, activating bone-marrow, and unblocking collaterals is effective on improving blood coagulation function by increasing the quality and amount of platelet.
