The changes of plasma VEGFin cerebral arteriovenous malformations
10.3969/j.issn.1006-5725.2017.23.012
- VernacularTitle:脑动静脉畸形治疗前后血浆血管内皮生长因子水平变化
- Author:
Gang ZHAO
1
;
Junchao LIANG
;
Huan YANG
;
Jingwen QUAN
;
Xiaoyan LIU
Author Information
1. 广州军区广州总医院神经外科
- Keywords:
abnormal vascular;
vascular growth factor;
cerebral arteriovenous malformation
- From:
The Journal of Practical Medicine
2017;33(23):3899-3901
- CountryChina
- Language:Chinese
-
Abstract:
Objective Todetectthe level of plasma VEGF before and after treatment of arteriovenous mal-formationpatients,and the pathophysiological role of VEGF in arteriovenous malformationpatientswas also studied. Methods The blood samples of 17 arteriovenous malformation patients were collected according to the following three groups:group before operation(AVM),group 24 hours after operation(AVM24h)and group 30 days after operation(AVM30d).As a control(Con),22 blood samples were collected from lumbar laminectomypatients.The level of plasma VEGF was determined by ELISA assay. Results Compared with the control group,the plasma VEGF was significantly decreased in AVM group and AVM24h group(P < 0.05),while the plasma VEGF in AVM30d groupwas similarto that of the control group. Conclusions Abnormal blood vessel plays an important pathophysiological role in cerebral arteriovenous malformation,and the metabolism of VEGF is involved in the pro-cess of arteriovenous malformation.
