Relationship between neuropeptide Y gene polymorphism and schizophrenia
10.3969/j.issn.1674-8115.2017.12.001
- VernacularTitle:神经肽Y基因多态性和精神分裂症的关联研究
- Author:
Jing ZHAO
1
;
yu Qin LÜ
;
Ying LU
;
qin Guo HU
;
xi Chen BAO
;
huan Ming ZHU
;
Si JIA
;
yan Xiao CHENG
;
jie Rui GENG
Author Information
1. 上海交通大学 医学院附属精神卫生中心
- Keywords:
neuropeptide Y;
schizophrenia;
association study;
single nucleotide polymorphism
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(12):1581-1587
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To explore the association between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population. Methods·Four single nucleotide polymorphism (SNP) loci (rs16148, rs1859290, rs16147, and rs16478 in NPY gene) were selected and genotyped by TaqMan genotyping assay in a case-control study with 678 schizophrenia cases (case group) and 685 healthy controls (control group). The allele, genotype and haplotype frequencies distribution of the SNPs between the groups were compared with SHEsis online software. Results·The distribution of genotype frequency of locus rs16478 showed a nominal statistically difference between the adult-onset schizophrenia (AOS group) and control group (χ2=6.66, P=0.036, P correction=0.144). Under recessive inherited model, the distribution of CC genotype frequency of locus rs1859290 showed statistically difference between the male schizophrenia cases and control group (P=0.012, OR=0.97, 95％CI 0.94-0.99, P correction=0.048). The distribution of haplotype CCTA (consisted of rs16148, rs1859290, rs16147, and rs16478) frequency showed statistically difference between the male AOS group and control group (8.1％ vs 13.2％, OR=0.57, P=0.010, P correction=0.040). Conclusion·The polymorphisms in NPY gene may be associated with schizophrenia in Chinese Han population.
