Expression of SATB2 and P53 in colorectal cancer and their clinical significance
10.3969/j.issn.1006-5725.2017.23.024
- VernacularTitle:SATB2和P53蛋白在结肠癌组织中的表达及临床意义
- Author:
Xiaohui JI
1
;
Jun LI
;
Jinhua YANG
Author Information
1. 郑州人民医院病理科
- Keywords:
colorectal cancer;
SATB2;
P53
- From:
The Journal of Practical Medicine
2017;33(23):3945-3948
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of SATB2 and P53 protein in colorectal cancer and to analyze their relationship with the clinical pathologic characteristics. Methods The expression of SATB2 and P53 protein in 30 normal colorectal tissues and 120 colorectal cancer tissues were detected by immunohistochemical method,then analyzed their correlation. Results The expression of SATB2 in colorectal cancer was lower than that in normal colorectal tissues(P<0.05);and its expression correlated with the tumor size,differentiation,inva-sion,depth,lymph node metastasis and TNM stages(P<0.05),while not with age and gender.The expression of P53 in colorectal cancer was significantly higher than that in normal colorectal tissues(P<0.01),and its expres-sion correlated with differentiation,invasion depth and TNM stages(P<0.05),while not with age,gender,tumor size and lymph node metastasis. The expression of SATB2 and P53 in colorectal cancer have negative correlation (P < 0.01). Conclusion Compared with in normal colorectal tissues,the expression of SATB2 declined and the expression of P53 increased in colorectal cancer,while they have negative correlation. The expression levels of SATB2 and P53 protein have important significance to evaluate the prognosis of colorectal cancer.
