Relationship between quantitative indices of carotid plaque from contrast-enhanced ultrasound and leukocytes in patients with acute large artery atherosclerotic stroke
10.3969/j.issn.1674-8115.2017.12.010
- VernacularTitle:急性大动脉粥样硬化性脑卒中患者颈动脉斑块超声造影定量指标与循环血白细胞的关系
- Author:
jun Zhao LI
1
;
bin Wan LI
;
Yun BAI
;
Qing YANG
;
fang Lian DU
;
hong Xiang LUO
Author Information
1. 上海交通大学附属第一人民医院 超声影像科
- Keywords:
contrast-enhanced ultrasound;
atherosclerosis;
stroke;
plaque;
leukocyte
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(12):1640-1643
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To investigate the relationship between quantitative indices of carotid plaques from contrast-enhanced ultrasound and leukocytes, and explore the value in the patients with acute large artery atherosclerotic stroke (LAAS). Methods·A total of 62 patients with LAAS and 48 matched control subjects hospitalized in Shanghai General Hospital, Shanghai Jiao Tong University from June 2016 to June 2017 were enrolled. Obvious carotid plaques were examined by contrast-enhanced ultrasound. The parameters of time-intensity curve i.e. peak (PTIC) and mean (MTIC), and the parameters of fitting curve i.e. peak (PFC), sharpness (SFC), and under the curve area (AUCFC) were obtained. These parameters were compared between the groups using two samples t tests. The correlations between the parameters and leukocyte counts were analyzed by Pearson correlation analysis. Results·① In LAAS group, the total leukocyte and neutrophil counts were higher than those of the control group, while the lymphocyte count was lower than that of the control group (P<0.05). ② The PTIC, MTIC, PFC, SFC and AUCFC were significantly larger in LAAS group than those in the control group, respectively (P<0.05).③ PTIC, MTIC and PFC were negatively correlated with lymphocytes, respectively (r=-0.291, -0.263 and -0.270, P<0.05). SFC and AUCFC were positively correlated with neutrophils, respectively (r=0.261 and 0.298, P<0.05). Conclusion·Quantitative indices of carotid plaques from contrast-enhanced ultrasound are associated with circulating leukocytes, and the association helps assess the vulnerability of the plaques.
