Distribution of HPV infection in laryngopharyngeal squamous cell carcinoma and laryngeal papilloma
10.16571/j.cnki.1008-8199.2017.12.008
- VernacularTitle:HPV感染在咽喉部鳞癌及喉乳头状瘤中的分布研究
- Author:
ying Hui HU
1
;
kun Zhen YU
;
ba Shuang HE
;
xiang Qing ZHANG
;
chun Shan GONG
;
dong Hai ZHANG
Author Information
1. 东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科
- Keywords:
Head and neck cancer;
Laryngeal papilloma;
Laryngeal cancer;
Human papilloma virus
- From:
Journal of Medical Postgraduates
2017;30(12):1264-1267
- CountryChina
- Language:Chinese
-
Abstract:
Objective Human papillomavirus (HPV) is presumed to be the cause of the development of head and neck squamous cell carcinoma.However,the current research results are not very sure.The article was designed to study the distribution of HPV infection in the tissues of laryngopharyngeal squamous cell carcinoma and laryngeal papilloma and its significance.Methods We collected samples of tissues from 67 patients who were treated in our hospital,including 41 cases of laryngeal papilloma,26 cases with laryngeal carcinoma,hypopharyngeal carcinoma,and oropharyngeal carcinoma.In the same period,20 cases of benign vocal cord polyps were treated as control group.PCR was applied in HPV typing test of fresh tumor tissues from operations,followed by the analysis on HPV infection type and distribution.Results In research group,44/67 cases was HPV-positive (65.7％),among which the HPV types of the laryngeal papilloma were HPVll (36/41) and HPV6 (4/41),and HPVI6 (6/26) in laryngeal carcinoma,hypopharyngeal carcinoma,and oropharyngeal carcinoma.While in control group,vocal cord polyps were HPV-negative without any multitype infection.Conclusion HPV16 may be a risk factor for the occurrence of laryngeal cancer and oropharyngeal cancer (non-alcoholic-induced or non-tobacco-induced cancer).HPV has high prevalence in Chinese laryngeal papilloma people,but HPV has low prevalence in Chinese laryngeal or hypopharyngeal carcinoma people.HPV testing of head and neck cancer is worth promoting.
