The Severity of Extent of Coronary Atherosclerosis Related to Plasma Homocysteine.
10.4070/kcj.2000.30.1.31
- Author:
Seung Hwan LEE
;
Jang Young KIM
;
Han Hyo LEE
;
Bong Ki LEE
;
Ji Yean KO
;
Byung Su YOO
;
Junghan YOON
;
Kyung Hoon CHOE
;
Kang Heun LEE
;
Sung Oh HWANG
- Publication Type:Original Article
- Keywords:
Homocysteine;
Coronary artery disease;
Atherosclerosis
- MeSH:
Atherosclerosis;
Cholesterol;
Constriction, Pathologic;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels;
Folic Acid;
Homocysteine*;
Humans;
Hyperhomocysteinemia;
Lipoproteins;
Plasma*;
Risk Factors;
Vitamin B 12;
Vitamins
- From:Korean Circulation Journal
2000;30(1):31-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND PURPOSE: Hyperhomocysteinemia is supposed to be a risk factor for vascular occlusive disease. We want to evaluate the relationship between plasma homocysteine and the severity of coronary artery disease (CAD). METHODS: In 121 consecutive patients (men:62%: age:60+/-10 years) undergoing coronary angiography, plasma homocysteine, vitamin B(12), vitamin B(6) and folate levels were measured and angiographic findings were evaluated for the number of diseased vessels (diameter stenosis 50%), severity of stenosis of CAD and extent of CAD. Extent of CAD was defined as an index derived by assigning a score of 0-3 per segment depending on the proportion of lumen length irregularity and dividing the sum by the number of visualized segments. RESULTS: Twenty-two patients had normal coronary artery: 35 patients, minimal CAD (diameter stenosis < 50%): 30 patients, 1 vessel disease (VD): 22 patients, 2VD and 12 patients, 3VD. Homocysteine levels w+re not significantly different between the groups (normal:7.6+/-4.2 mmol/L: minimal CAD:8.4+/-3.1mmol/L: 1VD: 8.0+/-4.8mmol/L: 2VDs: 10.2+/-6.0 mmol/L: 3VDs: 9.2+/-5.3 mmol/L). There was no relation between the stenosis scores of CAD and homocysteine levels (r=0.1). The extent scores of CAD were weakly correlated to the plasma homocysteine levels (r=0.22, p<0.05) and low density lipoprotein (LDL) cholesterol levels (r=0.28, p<0.01), and reversely correlated to high density lipoprotein (HDL) cholesterol levels (r=-0.31, p<0.01). The plasma homocysteine levels were reversely correlated to vitamin B12 (r=-0.27, p<0.01) and folate (r=-0.23, p<0.05) levels. In conclusion, the plasma homocysteine level was weakly but significantly correlated with the extent of CAD, not with the severity of stenosis.
