Functional connectivity of suprachiasmatic nucleus in major depressive episodes patients with morn-ing heavy night light rhythm
10.3760/cma.j.issn.1674-6554.2017.12.005
- VernacularTitle:伴晨重夕轻节律的抑郁发作患者视交叉上核功能连接特征研究
- Author:
Jiting GENG
1
;
Rui YAN
;
Zhaoqi MO
;
Yu CHEN
;
Jiabo SHI
;
Qing LU
;
Zhijian YAO
Author Information
1. 南京医科大学附属脑科医院精神科
- Keywords:
Depressive episode;
Diurnal rhythm;
Functional magnetic resonance;
Suprachi-asmatic nucleus;
Functional connectivity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(12):1081-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the variations of functional connectivity in depressive episode pa-tients with diurnal rhythm.Methods Totaly 44 patients with depressive episode with diurnal rhythm(rhythm group),58 patients with depressive episode without diurnal rhythm(non-rhythm group)and 56 matched healthy volunteer controls(healthy group)were scanned with 3.0 T MRI Scanner.Functional connectivity (FC)were calculated between suprachiasmatic nucleus(SCN)and whole brain regions.According to results of ANOVA,group-wise two sample t-test was completed.Correlation analysis were conducted between FC of significant difference brain regions and the score of Hamilton rating scale(HAMD-24)for depression.Results The brain regions showing differences among three groups were located in the left medial superior frontal gy-rus(MNI:x=0,y=39,z=51; K=14)and right cerebellum crus 1(MNI:x=39,y=-48,z=-36; K=18) (P<0.05,Alphasim).Compared with non-rhythm group,the FC of rhythm group showed significantly in-creased in the left medial superior frontal gyrus and right triangular inferior frontal gyrus(MNI:x=39,y=27, z=27;K=10)(P<0.05,Alphasim).Compared with healthy group,the FC of non-rhythm group showed sig-nificantly decreased in left medial superior frontal gyrus(P<0.05,Alphasim).Positive correlation was found be-tween FC in left medial superior frontal gyrus and despair score of HAMD-24(r= 0.31,P= 0.041). Conclusion The synergistic increase in SCN and prefrontal activity in patients with depressive episodes with morning heavy night light rhythm which may be involved in the formation mechanism of the diurnal rhythm.
