Clinical Observation of Chinese Medicinal Recipe Psoriasis No.1 Formula in Treating Blood-heat Type of Psoriasis
10.13359/j.cnki.gzxbtcm.2018.01.009
- VernacularTitle:中药银屑病一号方治疗血热型银屑病的疗效观察
- Author:
Zhou ZHU
1
;
Qun Li GU
;
Qi REN
;
Hui HUA
Author Information
1. 南通市第三人民医院
- Keywords:
blood-heat type of psoriasis;
Psoriasis No.1 Formula;
Compound Qingdai Capsules;
IL-17;
TNF-α
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2018;35(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of Chinese medicinal recipe Psoriasis No.1 Formula in treating blood-heat type of psoriasis. Methods Eighty patients with blood-heat syndrome were randomly divided into trial group and control group,40 cases in each group. The trial group was given oral use of the decoction of Psoriasis No . 1 Formula (mainly composed of Radix Rehmanniae, Rhizoma Imperatae, Cortex Moutan,Rhizoma Smilacis Glabrae,Radix Glycyrrhizae,Flos Sophorae,Radix Arnebiae seu Lithospermi, Radix Paeoniae Rubra, Folium Isatidis, Periostracum Cicadae, Radix Scutellariae, and Radix Angelicae Sinensis). The control group was given Compound Qingdai Capsules orally. The treatment for the two groups covered 8 weeks. Psoriasis Area Severity Index(PASI)scores,and contents of interleukin-17(IL-17)and tumor necrosis alpha (TNF-α)were observed before and after treatment. And clinical efficacy and adverse reactions were compared between the two groups after treatment. Results (1) PASI scores of the two groups were significantly lowered after treatment(P < 0.01 compared with those before treatment),and the trial group had stronger effect on decreasing PASI scores than the control group(P<0.05).(2)The total effective rate of the trial group was 87.5％,higher than the control group(67.5％),but the difference was insignificant(P > 0.05). (3)After treatment , contents of IL-17 and TNF-α of the two groups were markedly decreased(P < 0.01 compared with those before treatment),but the difference was insignificant between the two groups(P > 0.05). (4)No severe adverse effect was found in the two groups during the treatment. Conclusion Chinese medicinal recipe Psoriasis No.1 Formula is effective and safe in treating blood-heat type of psoriasis, and its effect is superior to that of Compound Qingdai Capsules.
