Application of Laboratory Indexes in Traditional Chinese Medicine Syndrome Differentiation of Multiple Myeloma
10.13359/j.cnki.gzxbtcm.2018.01.012
- VernacularTitle:实验室指标在多发性骨髓瘤辨证分型中的应用
- Author:
Feng Ming XIAO
1
;
Duo Ji LIU
;
Qing YUAN
;
Ping Guang LIU
Author Information
1. 广州中医药大学第一附属医院
- Keywords:
multiple myeloma;
traditional Chinese medicine(TCM)syndrome types;
laboratory indexes
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2018;35(1):55-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between traditional Chinese medicine (TCM)syndrome differentiation of multiple myeloma(MM)and laboratory indexes of MM,thus to supply evidence for the syndrome differentiation of MM. Methods A total of 59 MM patients were enrolled in the study. TCM syndrome differentiation was performed. And we also collected the laboratory indexes of serum protein electrophoresis (SPE),immunofixation electrophoresis (IFE),blood urea nitrogen (BUN),creatinine (CREA),serum beta 2 microglobulin,serum calcium(Ca),hemoglobin(Hb),Bence Jones protein,flow cytometric-immunophenotyping(FCM) and bone marrow cytology. The differences of the laboratory indexes in various syndrome types of MM were analyzed. Results No significant differences were found in myeloma cell morphology, M protein content, IFE typing results, Bence Jones protein positive rate and the concentration of Ca of various syndrome types of MM (P >0.05). However,the concentrations of BUN,CREA,serum beta 2 microsglobulin,Hb,and the positive rates of CD19- and CD56+ were significantly different in various syndrome types of MM (P < 0.05 or P < 0.01). Moreover,Hb,BUN,CREA,and serum beta 2 microspheres were significantly correlated with each other(P<0.05 or P < 0.01). Conclusion Hb, BUN, CREA, blood beta 2 microglobulin and FCM detection can be sued for the auxiliary diagnosis of syndrome types of MM, and for preliminary demonstration of illness severity and prognosis. The results will provide the basis for the treatment of MM with traditional Chinese medicine and western medicine.
