Effect mechanism of α-adrenoceptor on sepsis-induced acute respiratory distress syndrome
10.3760/cma.j.issn.2095-4352.2018.01.016
- VernacularTitle:α-肾上腺素能受体在脓毒症致ARDS中的作用机制
- Author:
Xiangpeng LYU
1
;
Zhukai CONG
;
Dan LI
;
Yifan TAO
;
Xi ZHU
Author Information
1. 100191,北京大学第三医院危重医学科
- Keywords:
Acute respiratory distress syndrome;
Sepsis;
Stress;
α-adrenergic receptor
- From:
Chinese Critical Care Medicine
2018;30(1):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure (MOF) in the lung, which often caused by various non-cardiac reasons, included severe trauma, infection, shock; and the most common risk factor is sepsis which would cause uncontrolled host response to infecting factors. As a strong stressor during sepsis, the severe infectious state of the body triggers serious stress reaction. The hypothalamus-pituitary-adrenal cortical (HPA) axis and sympathetic-adrenal medulla axis were activated and participated the initiation and progression of the stress response through the production of adrenocorticotropic hormone (ACTH), glucocorticoid (GC), epinephrine and norepinephrine (NE). As the main hormones during sepsis, catecholamines (CA), including epinephrine and NE, could bind to adrenergic receptor (AR). After the binding, CA could play its role through the complicated signal way. Therefore, to explore the signal transduction pathway of α-AR, during sepsis, is important for revealing the mechanism of sepsis-induced ARDS.
