Roles of macrophage-mediated epithelial mesenchymal transdifferentiation in fibrotic diseases

VernacularTitle:巨噬细胞介导上皮间充质转分化在纤维化疾病中的作用
Author: Qianqian ZHANG ¹ ; Xiaohui ZHOU ; Lunxian TANG
Author Information

1. 同济大学医学院
Keywords: Macrophage; Epithelial mesenchymal transdifferentiation; Fibrosis
From: Chinese Critical Care Medicine 2018;30(1):91-93
CountryChina
Language:Chinese
Abstract: It is reported that fibrotic changes seemed to be associated with poor prognosis in patients with organ dysfunction, unfortunately no effective treatment existed currently. Recent studies have demonstrated that macrophages can interact with epithelial cells to induce epithelial mesenchymal transdifferentiation (EMT) which is thought to play a key role in the pathogenesis of a variety of fibrotic diseases. Therefore, this review will summarize the potential role of macrophages in the molecular mechanisms of EMT-associated fibrosis. We aimed to provide a possible therapeutic approaches for the fibrotic diseases.