Clinical Study on Yiqi Huoxue Huatan Yangxin Decoction for Treatment of Unstable Angina Pectoris
10.3969/j.issn.1005-5304.2018.01.004
- VernacularTitle:益气活血化痰养心汤辅助治疗不稳定型心绞痛临床研究
- Author:
Juan WU
1
;
fu Chou CHENG
Author Information
1. 湖南中医药大学中医学院
- Keywords:
unstable angina pectoris;
Yiqi Huoxue Huatan Yangxin Decoction;
clinical study
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of Yiqi Huoxue Huatan Yangxin (IHHY) Decoction for treatment of unstable angina pectoris patients. Methods Totally 165 cases of patients with unstable angina pectoris were collected and divided into observation group (84 groups) and control group (81 patients) by semi-random method. Patients in both groups received western medical, and patients in observation group were added with IHHY Decoction, one dosage a day, twice a day, orally. The therapeutic course for both groups was 4 weeks, with 4 weeks follow up. Angina pectoris grade and ECG effect in both groups were observed. Blood viscosity, fibrinogen, serum NO, superoxide dismutase (SOD), plasma levels of endothelin (ET), thromboxane B2 (TXB2), 6-keto-PGF1α, were measured, and TCM syndrome score was observed. The incidence of all adverse reactions was recorded. Results After treatment, the angina pectoris grade of both groups were lower than before, with statistical significance (P<0.05). The total effective rate of ECG was 69.0% (58/84) in the observation group and 65.4% (53/81) in the control group, without statistical significance (P>0.05). Compared with before treatment, whole blood viscosity, plasma fibrinogen, levels of ET and TXB2 decreased, while the levels of NO and 6-keto-PGF1αincreased (P<0.05). Whole blood viscosity, plasma fibrinogen, levels of ET and TXB2 in the observation group were lower than the control group after treatment, while the level of NO was higher than the control group, with statistical significance (P<0.05). There was no statistical significance in TCM syndrome before and after treatment in both groups. There was no abnormality in liver and kidney. Conclusion On the basis of routine treatment, IHHY Decoction can significantly relieve the symptoms of unstable angina and maintain the balance of vasoconstriction and platelet aggregation.
