Optimization of Dry Granulation Technology of Typha Pollen Granules by Box-Behnken Design and Response Surface Method
10.3969/j.issn.1005-5304.2018.01.018
- VernacularTitle:Box-Behnken设计-效应面法优选蒲黄干法制粒工艺
- Author:
yun Ling FAN
1
;
Yan YU
;
de Jian GAO
;
Hui JIN
Author Information
1. 甘肃中医药大学
- Keywords:
Typhae Pollen;
Box-Behnken design-response surface method;
dry granulation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(1):84-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the dry granules process of Typha Pollen. Methods The particle size and particle friability were selected as evaluation indexes. The inspect factors were water content, compression frequency, and granulation frequency. Influence of inspect factors on evaluation indexes was investigated by single factor test, the influence of inspect factors on OD value was investigated by Box-Behnken design, and response surface method was adopted to predict, analyze and choose optimal process. Results The optimal dry granulation technology was as follows: the water content was 35.0%; the frequency of tabletting was 27 Hz; the granulating frequency was 15 Hz. Conclusion The selected process is stable, feasible and reproducible, which can be used for granulation of Typha Pollen granules.
