Relationship between thioredoxin-interacting protein and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia
10.3969/j.issn.1006-6187.2017.12.006
- VernacularTitle:糖耐量减低合并高甘油三酯血症患者硫氧还原蛋白相互作用蛋白与胰岛功能的相关性研究
- Author:
Yongcai ZHAO
1
;
Guangyao SONG
;
Xinsheng LI
Author Information
1. 061001,沧州市中心医院内分泌科
- Keywords:
Impaired glucose tolerance;
Hypertriglyceridemia;
Thioredoxin-interacting protein;
β-cell dysfunction.
- From:Chinese Journal of Diabetes
2017;25(12):1086-1089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between thioredoxin-interacting protein(TXNIP) and pancreaticβ-cell function in impaired glucose tolerance patients with and without hypertriglyceridemia. Methods A total of 267 subjects were enrolled in this study and divided into three groups:impaired glucose tolerance(IGT)group(n= 90),impaired glucose tolerance and hypertriglyceridemia(IGT +HTG)group(n=87)and normal glucose tolerance(NGT)group(n=90). The levels of plasma TXNIP were measured. Intravenous glucose tolerance test was performed to evaluate the first-phase insulin response(FPIR). HOMA forβ-cell function(HOMA-β)was calculated to evaluate basal pancreatic β-cell function. Results TXNIP was significantly higher in IGT group than in NGT group(P＜ 0.05). TXNIP was much higher in IGT+ HTG group than in IGT group (P＜0.05). HOMA-βand FPIR were decreased gradually from NGT,IGT to IGT + HTG(P＜0.05). Correlation analysis showed that HOMA-β and FPIR were negatively correlated with TXNIP(P＜ 0.05). Conclusion The level of TXNIP is increased in IGT,especially in IGT with hypertriglyceridemia. Basal and first-phase isletβ-cell function are all associated with TXNIP.
