Effect of different fluid resuscitation strategies on respiratory mechanics and oxygenation in patients with septic shock
10.3969/j.issn.1671-8348.2017.36.014
- VernacularTitle:不同液体复苏策略对脓毒性休克患者呼吸力学及氧合的影响
- Author:
Daoye LIANG
1
;
Chunlin MA
;
Juanjuan XIE
Author Information
1. 广西中医药大学第一附属医院ICU
- Keywords:
shock;
septic;
respiratory mechanics;
respiratory mechanics;
Oxygenation
- From:
Chongqing Medicine
2017;46(36):5081-5082,5085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of different fluid resuscitation strategies on respiratory mechanics and oxygena-tion in the patients with septic shock .Methods The treatment data in 125 patients with septic shock in ICU of this hospital were retrospectively investigated and analyzed .The patients were divided into the restriction fluid resuscitation group (n=58) and open fluid resuscitation (n=67) according to fluid resuscitation results .The changes of respiratory mechanics (static lung compliance ,in-spiratory resistance) and oxygenation before and after resuscitation were compared between the two groups .Meanwhile the hemo-dynamics and vasoactive drugs application were recorded in the two groups .Results The hemodynamic indicators had no statistical difference between the two groups .The use amounts and use time of vasoactive drugs in the open fluid resuscitation group were less than those in the restriction fluid resuscitation group (P<0 .01);the airway resistance in the two groups had no obvious change be-tween before and after resuscitation ,the lung compliance and oxygenation in the restriction fluid resuscitation group were superior to those in the open fluid resuscitation group (P<0 .01) .With the fluid resuscitation amount increase ,the lung compliance in the re-striction fluid resuscitation group and open fluid resuscitation group were progressively poorer ,which was especially obvious in the open fluid resuscitation group(P<0 .01);the amount of fluid resuscitation was negatively correlated with the lung compliance and oxygenation (R= -0 .783、-0 .860 ,P<0 .01) .Conclusion In treating septic shock ,although the open resuscitation strategy has smaller dose and use time of vasoactive drugs ,but the lung compliance and oxygenation are affected ,while the restriction fluid re-suscitation strategy is in contrast .
