Expression and significance of autophagic regulatory factor mTOR and Beclin1 in benign and malignant pleomorphic adenoma
10.3969/j.issn.1671-8348.2017.36.015
- VernacularTitle:自噬调控因子mTOR和Beclin1在良恶性多形性腺瘤中的表达及意义
- Author:
Lei LI
1
;
Ran LI
;
Jiang LIU
;
Rui LIU
;
Guohai YANG
;
Yanbo ZHANG
Author Information
1. 承德医学院附属医院口腔科
- Keywords:
autophagy;
tacrolimus binding proteins;
Beclin 1;
carcinoma in pleomorphic adenoma
- From:
Chongqing Medicine
2017;46(36):5083-5085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of main autophagic regulatory factors of mTOR and Beclin 1 in benign and malignant pleomorphic adenoma .Methods The expression of Beclin1 in 35 cases of carcinoma in parotid pleomorphic adenoma(CPA) ,37 cases of benign pleomorphic adenoma(PA) and 20 cases and normal parotid tissues was measured by adopting the immunohistochemical staining method .The expression of p-mTOR and Beclin1 in CPA ,PA and normal parotid tissues was measured by Western blot .Results The positive expression of p-mTOR in normal parotid tissue ,parotid pleomorphic adenoma and parotid pleomorphic adenoma showed the increasing trend ,and the difference among them was statistically significant (P<0 .05) . The Beclin1 level in 3 kinds of tissue showed the descending trend ,the difference among the three tissues was statistically signifi-cant(P<0 .05) .Conclusion mTOR signal factor is over-expressed in CPA tissue ,while the positive expression of Beclin 1 is inhibi-ted in CPA tissue .
