Clinical Value of Serum S100-beta Protein in the Diagnosis and Prognosis of Patients with Closed Craniocerebral Injury
10.3969/j.issn.1671-7414.2017.05.016
- VernacularTitle:血清S100-β蛋白对闭合性颅脑损伤患者诊断及预后临床价值的研究
- Author:
Na ZHU
1
;
Bo CHEN
;
yan Xiao ZHANG
;
yu Feng XI
;
xia Li ZHANG
Author Information
1. 陕西省人民医院科研处
- Keywords:
S100-beta protein;
craniocerebral injury;
biochemical markers
- From:
Journal of Modern Laboratory Medicine
2017;32(5):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the level of S100-β protein in the serum of patients with closed craniocerebral injury and analyze its clinical value to assess the diagnosis and prognosis of the disease.Methods The expression of quantitative analysis method to detect 31 cases of healthy control group,40 cases of patients with severe craniocerebral injury and 34 cases of craniocerebral injury patients on admission S100-β protein level by the receiver operating characteristic curve (ROC) analysis,to explore the correlation between the prognosis of GOS,closed craniocerebral injury diagnosis efficacy.Results In the control group,mild and severe closed craniocerebral injury group S100-β protein levels were 0.137 ±0.025,0.192 ± 0.038 and 0.276 ±0.097 ng/ml,respectively.Compared with the control group (F=0.126,P=0.008),light and heavy closed craniocerebral injury group (F=38.17,P=0.001) of serum S100-β protein levels were significantly increased,the difference was statistically significant (P＜0.01).There were significant differences in the level of serum S100-β light and heavy craniocerebral injury group (P＜0.05).Serum S100-βprotein differential control group and brain injury group AUC 0.870 (95％ CI:0.776 ～ 0.964,P＜ 0.01).S100-β protein identification in healthy control group with severe craniocerebral injury group AUC was 0.914 (95 ％ CI:0.850～0.978,P＜ 0.01).The score was negatively correlated with serum S100-β protein level and the prognosis of craniocerebral injury in GOS (r=-0.792,P＜0.01).Conclusion S100-β protein significantly increased in serum of light and heavy closed craniocerebral injury patients,and negatively correlated with the GOS score of patients,can be used for the auxiliary diagnosis and prognosis of craniocerebral injury.
