Paraquat poisoning mechanism and its clinical treatment progress

VernacularTitle:百草枯中毒机制及临床治疗进展
Author: Baisheng SUN ¹ ; Yuezhong HE
Author Information

1. 解放军第三〇七医院急诊科
Keywords: Paraquat; Poisoning mechanism; Lung injury; Treatment progress
From: Chinese Critical Care Medicine 2017;29(11):1043-1046
CountryChina
Language:Chinese
Abstract: Paraquat (PQ) as a kind of sterile and herbicides, has effects of contact-kill and systemic action, which can be absorbed quickly by green plants and make them wither and die. Therefore, it is widely used in the agricultural production and occupies a large part in our country's pesticide market. PQ poisoning has become one of the most common pesticide poisoning in our country. PQ can be passivated when combining with soil, but it has great toxicity for human. There are still no specific antidotes for PQ poisoning at home and abroad, and the death rate of PQ oral poisoning is up to 95%. Clinically comprehensive treatment is adopted, including gastric lavage, intentional diarrhea, diuresis and blood perfusion. However, the therapeutic effect is not good and the case fatality rate keeps high. It has become one of the hot issues for emergency medicine study to search PQ's special efficiency measures. This paper briefly reviews PQ's poisoning mechanism and its clinical treatment progress to provide new exploration direction and treatment ideas for basic research and clinical treatment of PQ.