Rosiglitazone alleviates vascular endothelial dysfunction in type 2 diabetic rats
10.3969/j.issn.1001-6325.2017.11.017
- VernacularTitle:罗格列酮减轻2型糖尿病大鼠血管内皮功能受损
- Author:
ye Li HU
1
;
yao Guang SONG
;
yun Lyu ZHU
;
Chao WANG
;
ling Xiao LI
;
ling Shao YANG
Author Information
1. 中国人民解放军白求恩国际和平医院内分泌科
- Keywords:
diabete rat;
nitric oxide;
endothelia nitric oxide synthase;
aorta;
rosiglitazone
- From:
Basic & Clinical Medicine
2017;37(11):1585-1589
- CountryChina
- Language:Chinese
-
Abstract:
To observe metabolic abnormalities, histology changes and eNOS expression of aorta in type 2 diabetes rat.And to observe intervention effect of rosiglitazone.Methods 80 male Wistar rats were randomized to control group, high diet group, diabetes group, and rosiglitazone treatment group (diabetes plus rosiglitazone treatment).Type 2 diabetes models were developed and rosiglization group was treated with rosiglitazone .Six weeks and twelve weeks after treatment with rosiglitazone, blood glucose, endothlin and nitric oxide were tested.Histology changes of aorta in different groups were observed under microscopy .Meanwhile the protein and mRNA expression of eNOS in aorta were examined.Results 1)Compared with control group, ET in high fat diet group, diabetes group and rosiglitazone group increased significantly , and the level of NO decreased significantly at 6 week and 12 week.At 12 week, ET in diabetes group increased, and NO decreased significantly than that of high fat diet group and rosiglitazone group.2)Histology changes were observed in high fat diet group , diabetes group and rosiglitazone group at 12 week.3)Compared with control group, protein and mRNA expression in high fat diet group , diabetes group and rosiglitazone group were down regulated at 6 week and 12 week.And protein expression in diabetes group was down regulated than that in rosiglitazone group .Conclusions Rosiglization can ease the endothelial dysfunction in type 2 diabetes rat.
