Influence of intensive atorvastatin therapy on CIN and inflammatory response in patients with ischemic cerebrovascular disease after interventional surgery
10.3969/j.issn.1008-0074.2017.06.11
- VernacularTitle:阿托伐他汀强化治疗对缺血性脑血管疾病患者介入术后CIN及炎症反应的影响
- Author:
Juan LI
1
;
Hong WANG
;
lian Shou WANG
Author Information
1. 西安市第九医院神经内科
- Keywords:
Brain ischemia;
Cerebral angiography;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(6):623-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence of intensive atorvastatin therapy on contrast-induced nephropathy(CIN) and systemic inflammatory response in patients with ischemic cerebrovascular disease(ICD)after interventional sur-gery.Methods:A total of 118 ICD patients undergoing interventional surgery in our hospital were selected.Accord-ing to atorvastatin dose,they were divided into intensive group(n=59,received atorvastatin 80mg/d before surgery and 40mg/d after surgery)and routine control group(n=59,received atorvastatin 20mg/d 3d before surgery and af-ter surgery).Levels of renal function indexes and inflammatory indexes 24h before and 72h after surgery were com-pared between two groups.Results:Compared with before treatment,after treatment,there was significant rise in cystatin C(CysC)level in intensive group;significant rise in levels of serum CysC,creatinine(Scr),and β2-micro-globulin(β2-MG),and significant reduction in creatinine clearance rate(Ccr)in routine control group(P<0.05 or<0.01);compared with routine control group after treatment,there were significant reductions in levels of Scr [(93.97 ± 13.83)μmol/L vs.(78.44 ± 17.36)μmol/L],β2-MG[(2.88 ± 0.64)mg/L vs.(2.46 ± 0.61)mg/L] and CysC[(1.24 ± 0.07)mg/L vs.(0.88 ± 0.10)mg/L],and significant rise in Ccr[(68.92 ± 17.38)ml/min vs. (82.22 ± 15.94)ml/min]in intensive group,P=0.001 all.There were significant reductions in inflammatory index levels in both groups after surgery,compared with routine control group,there were significant reductions in levels of high sensitive C reactive protein[(13.53 ± 3.82)mg/L vs.(11.31 ± 3.72)mg/L],interleukin-6[(99.87 ± 24.76)ng/L vs.(85.73 ± 24.17)ng/L]and tumor necrosis factor α[(286.67 ± 78.38)ng/L vs.(252.61 ± 80.02) ng/L]in intensive group,P<0.05 or <0.01. Incidence rate of CIN in intensive group was significantly lower than that of routine control group(1.69% vs.11.90%,P=0.028).Conclusion:Intensive atorvastatin therapy can sig-nificantly lower incidence rate of CIN and inhibit systemic inflammatory response in ICD patients after intervention -al surgery,and it′s safe and reliable.
