Progress in isoniazid resistant mutant genes and molecular detection methods of Mycobacterium tuberculosis
10.11958/20170876
- VernacularTitle:结核分枝杆菌耐异烟肼突变基因及分子检测方法研究进展
- Author:
lin Qian LI
1
;
min Fu FENG
;
hei Er DAI
Author Information
1. 华北理工大学公共卫生学院 063210
- Keywords:
Mycobacterium tuberculosis;
Isoniazid;
drug resistance gene;
molecular diagnosis;
review
- From:
Tianjin Medical Journal
2017;45(12):1341-1344
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis is a chronic infection caused by Mycobacterium tuberculosis. The high financial burden and high incidence rate of tuberculosis have become a critical public health problem in China. Isoniazid, as one of the important first-line drugs in the treatment of clinical patients, drug resistance is becoming increasingly serious because of the lack of standard treatment. At present, the main mechanism of isoniazid resistance is known as gene mutation. How to detect drug resistance gene effectively and accurately is the key to control tuberculosis. In this article, we analyzed the frequent genes (katG, inhA, ndh, ahpC and oxyR) and novel genes (kasA, sigI, furA, mabA, iniABC and efpA) from the perspective of molecular biology, and summarized their diagnostic methods.
