Advances in Study on NPRL2 Gene and Oxaliplatin in Treatment of Colorectal Cancer
10.3969/j.issn.1008-7125.2017.12.012
- VernacularTitle:NPRL2基因与奥沙利铂治疗结直肠癌的研究进展
- Author:
Weiran FU
1
;
Aiyun LIU
;
Yaju DU
Author Information
1. 哈尔滨医科大学附属第二医院消化内科 150001
- Keywords:
Colorectal Neoplasms;
NPRL2 Gene;
Oxaliplatin;
Therapy
- From:Chinese Journal of Gastroenterology
2017;22(12):760-763
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer (CRC)is one of the three major malignant tumors in the world with high morbidity and mortality. It is found that NPRL2 gene is closely related to the occurrence and development of CRC,and the expression of NPRL2 gene in CRC patients is significantly reduced. Oxaliplatin is the third generation of platinum anticancer drugs,and has been widely used in the chemotherapy of gastrointestinal tumors. Oxaliplatin can improve the survival rate of CRC patients,but some patients have drug resistance. NPRL2 gene can increase the sensitivity of oxaliplatin in the treatment of CRC,and is a potential target for treatment of CRC. This article reviewed the advances in study on NPRL2 gene and oxaliplatin in the treatment of CRC.
