The effects of Spirulina kinase in rats with acute blood stasis
10.3969/j.issn.1671-8348.2017.36.003
- VernacularTitle:螺旋藻激酶对急性血瘀模型大鼠的影响
- Author:
Yuanheng HUANG
1
;
Feizhang QIN
;
Yingxin LI
;
Chunlan YUAN
;
Limei JIANG
;
Lin WANG
;
Hui PANG
Author Information
1. 广西医科大学基础医学院
- Keywords:
Spirulina kinase;
blood stasis;
hemorheology;
platelet aggregation;
cAMP
- From:
Chongqing Medicine
2017;46(36):5047-5048,5051
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this study ,the effect of Spirulina kinase(SPK)on hemorheology ,platelet aggregation and cAMP in acute blood stasis rats model were investigated .Methods Forty SD rats were randomly divided into normal control group ,model group ,aspirin group and the high and low dose of SPK groups .All treatments were performed by gavage once a day for 7 days .Sub-cutaneous injection of adrenalin combined with ice water bath were used to establish the acute blood stasis rat model .The whole blood viscosity ,plasma viscosity ,red blood cell hematocrit (Hct) ,erythrocyte aggregation index (EAI) ,red blood cell deformation index(DI)anderythrocyterigidityindex(ERI)weredetectedbyautomaticbloodflow speedanalyzer .Meanwhile,thelevelofcAMP was detected by ELISA method .Rat platelet aggregation induced by ADP and the maximum aggregation rate was measured by tur-bidimetry .Results Results showed that SPK could significantly decrease the whole blood viscosity ,plasma viscosity ,Hct ,EAI and platelet aggregation rate ,increase the level of cAMP compared with model group(P<0 .05) ,but had no effect on DI and ERI .Con-clusion SPK can markedly improve the abnormal changes of hemorheology in acute blood stasis rats and inhibit the platelet aggregation .
