Research progress on the role of SIRT in intestinal barrier
- VernacularTitle:SIRT在肠屏障中作用的研究进展
- Author:
Jie CHEN
1
;
hua Jian WAN
;
yan Dang WU
;
Liang XIA
Author Information
1. 南昌大学第一附属医院消化内科
- Keywords:
SIRT;
protein deacetylase;
intestinal barrier
- From:
Basic & Clinical Medicine
2018;38(1):103-106
- CountryChina
- Language:Chinese
-
Abstract:
SIRT is a family of highly conserved nicotine adenine dinucleotide ( NAD+)-dependent protein deacetylase which regulates several processes including cell gene stability , metabolism , aging and apoptosis . Studies have shown that SIRT has protective effects on intestinal barrier , which influences the structure and function of intestinal barrier by controlling the release of inflammatory cytokines , regulating the expression of tight junction protein in intestinal epithelial , and changing the number of Paneth and goblet cells in the intestine .
