Study on the Effect of Ginkgo Biloba Extract on Optic Nerve in Progressive Normal-tension Glaucoma Patients
10.16466/j.issn1005-5509.2017.12.013
- VernacularTitle:金纳多口服液对进展性正常眼压性青光眼 视神经保护作用的临床研究
- Author:
Hongbo HAN
1
;
Chunzi LIU
Author Information
1. 浙江中医药大学附属第一医院 杭州 310006
- Keywords:
Ginkgo biloba extract;
normal intraocular pressure;
glaucoma;
hemodynamics;
visual field;
retinal nerve fiber layer thickness;
rim area
- From:
Journal of Zhejiang Chinese Medical University
2017;41(12):984-989
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To evaluate the effect of Ginkgo biloba extract on optic nerve in progressive normal-tension glaucoma patients. [Methods] 60 cases of patients suffered from controlled normal-tension glaucoma were randomly divided into control and treatment groups, 30 cases in each respectively. The patients in the control group received the conventional treatment(eye drops or surgical treatment), additionally the patients in the treatment group received Ginkgo biloba extract(twice a day ,1ml each time). 5 months was a therapeutic course, after 3 therapeutic courses the best corrected visual acuity, ocular hemodynamics, visual field, retinal nerve fiber layer thickness and optic disc data were detected and statistically studied. [Results] There was no significant difference in the best corrected visual acuity between control group and treatment group( P>0.05). The end diastolic velocity(EDV), peak systolic velocity(PSV) were increased significantly and resistive index(RI) was decreased significantly in treatment group after treatment( P<0.05), while the EDV, PSA, RI in control group before and after treatment were without significant differences( P>0.05). The mean visual field defects(MD) in treatment group after treatment were much lower than the control group( P<0.05). The reduction trends of the retinal nerve fiber layer thickness and rim area in treatment group after treatment were slower than control group significantly decreased( P<0.05). [Conclusion] Ginkgo biloba extract can improve the ocular hemodynamics, delay the deterioration of the best corrected visual acuity and visual field damage, extend the losing time of visual retinal nerve fiber layer thickness and rim area. It has protective effect on optic nerve in normal-tension glaucoma.
