Hutchinson-Gilford progeria syndrome in two brothers and literature review
10.3969/j.issn.1000-3606.2017.12.005
- VernacularTitle:早老症一家系2例报告及文献回顾
- Author:
Fei CHENG
1
;
Mei CHEN
;
Jinzhun WU
;
Junmin ZHOU
;
Qingtan YAN
Author Information
1. 福建中医药大学附属厦门市第三医院儿科 福建厦门 361100
- Keywords:
Hutchinson-Gilford progeria syndrome;
NBAS gene;
gene mutation
- From:
Journal of Clinical Pediatrics
2017;35(12):898-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the clinical features, diagnosis and treatment of Hutchinson-Gilford progeria syndrome (HGPS). Methods The clinical data and gene testing results of HGPS in two brothers in the same family were retrospectively analyzed. The related literatures were reviewed. Results The proband was 15 years old, and his younger brother was 6 years old. Both of them presented premature appearance at 4 years old and 1 year-old respectively. Both of them suffered from underweight, short stature, reduced subcutaneous fat, bird face (prominent eyes, facial skin, scalp veins exposure, hook and prominent nose, mandibular stenosis). In addition, their trunk and limbs skin was relaxation, and they had ankylosis,and shrill voice etc.In both of them,the compound heterozygous mutation of NBAS gene(c.4081C>T,c.5741C>T)were found by full sequence exon sequencing, which were inherited from their father and mother respectively. The literature review suggested that NBAS gene mutation was associated with the diseases with main phenotype of short stature and optic atrophy.Conclusions It is reported two cases of HGPS caused by NBAS gene mutation.It is rare that two brothers have HGPS.
