Clinical value and inference prognosis of plasma perfusion combined with hemofiltration in the treatment of acute paraquat poisoning lung injury and prognosis

VernacularTitle:血浆吸附灌流联合血液滤过对急性百草枯中毒肺损伤的疗效及预后推断
Author: Xian CHEN ¹ ; jing Yu WU ; ke Hai DU
Author Information

1. 武警后勤学院附属医院急诊科 300162
Keywords: paraquat; poisoning; plasma perfusion; hemofiltration; acute lung injury
From: Tianjin Medical Journal 2017;45(12):1312-1315
CountryChina
Language:Chinese
Abstract: Objective To observe the curative effect of plasma perfusion (PP) combined with continuous veno-venous hemofiltration (CVVH) on different degrees of paraquat poisoning induced acute lung injury (ALI), and assess its clinical value for treatment of paraquat poisoning. Methods Data of 197 patients with paraquat poisoning hospitalized in our hospital from June 2013 to April 2017 were retrospectively analysed, including 128 cases with mild-to-moderate poisoning (5 mg·h/L≤SIPP≤25 mg·h/L) and 69 cases with severe poisoning (25 mg·h/L0.05). (2) There was no significant difference in the occurrence time of irreversible lung injury between two groups of patients with different degrees of poisoning (P>0.05). (3) The blood toxicant concentration of 4.35 mg·h/L and SIPP value 19.35 mg·h/L were used as a critical indicator of prognosis in treatment group. Conclusion Plasma perfusion combined with continuous veno-venous hemofiltration can obviously reduce the incidence of paraquat poisoning of lung injury in mild-to-moderate patients, but which has no obvious influence on the occurrence time.