Study on the role of miRNA-183 family in malignant cancer
- VernacularTitle:miRNA-183家族在恶性肿瘤中作用的研究
- Author:
li Zi ZHANG
1
;
liang Jin WANG
;
chao Xiang MENG
Author Information
- Keywords: microRNAs; breast neoplasms; prostatic neoplasms; lung neoplasms; digestive system neoplasms; miRNA-183 family
- From: Tianjin Medical Journal 2017;45(12):1337-1340
- CountryChina
- Language:Chinese
- Abstract: MiRNAs have a close relation with the development of malignancy. As a new type of regulatory factor, miRNA plays an important role in the development and progression of tumors, and plays the role of oncogene or tumor suppressor gene. Abnormal expression of miRNA is found in tumors. Most of the abnormal expression of miRNA are related to tumor staging, malignancy, treatment and prognosis, which provides a new strategy for the evaluation of early diagnosis, treatment and prognosis of tumors. The miRNA-183 family is composed of three types of miRNAs including miRNA-96, miRNA-182 and miRNA-183. They present abnormal expressions in tumors of digestive system, urogenital system and respiratory system. More and more researches have been done on the relationship between miRNA-183 family and tumor, and the mechanism has been deeply studied.
