Effect of Gastrodin on Gastric Sensitivity and Anxiety-like Behavior in FD Rats With Anxiety-like Gastric Hypersensitivity
10.3969/j.issn.1008-7125.2017.12.006
- VernacularTitle:天麻素对焦虑样胃高敏感FD模型大鼠胃敏感性和焦虑样行为的影响
- Author:
Fuchun JING
1
,
2
;
延安大学附属宝鸡市人民医院消化内科
;
Jun ZHANG
;
Jinhai WANG
;
Cheng FENG
;
Baode YANG
;
Hao HU
;
Xiaoming SUN
;
Jianyun ZHENG
;
Xiaoran YIN
;
Yuanyuan NIAN
Author Information
1. 西安交通大学第二附属医院消化内科 710004
2. 延安大学附属宝鸡市人民医院消化内科
- Keywords:
Gastrodin;
Anxiety;
Gastric Hypersensitivity;
Dyspepsia
- From:
Chinese Journal of Gastroenterology
2017;22(12):733-737
- CountryChina
- Language:Chinese
-
Abstract:
Background:Functional dyspepsia (FD)with anxiety and gastric hypersensitivity is still one of the therapeutic difficulties in clinic. Gastrodin (Gas)may have dual effects of modulating gastric sensitivity and anxiety. Aims:To investigate the effect of Gas on gastric sensitivity and anxiety-like behavior in FD with anxiety-like gastric hypersensitivity in rats. Methods:Forty rats were randomly divided into control group,model group,buspirone group,low-dose Gas group and high-dose Gas group. Maternal separation,acute gastric irritation and restraint stress were sequentially performed to induce FD model with anxiety-like gastric hypersensitivity. At the 8th week,rats in control group and model group were intraperitoneally injected with 0. 9% NaCl solution 2. 0 mL/ kg,rats in buspirone group were given buspirone 3. 125 mg/kg,and rats in low- and high-dose Gas groups were given 62. 5,125. 0 mg/ kg Gas,respectively. The course was 7 days. Then elevated plus maze (EPM),open field test,abdominal withdrawal reflex (AWR)and electromyography (EMG) were performed. Results:Compared with control group,EPM test showed that proportions of open arms entries and duration were significantly decreased (P < 0. 01);open field test showed that virtual central grids duration (P < 0. 05),number of virtual grids climbed and times of lifting were significantly decreased (P < 0. 01);when gastric balloon dilatation pressure was equal or greater than 40 mm Hg,AWR score,area under ROC curve (AUC)of EMG was significantly increased in model group (P < 0. 05). Compared with model group,above-mentioned indices in low- and high-dose Gas groups were significantly ameliorated (P < 0. 05). Conclusions:Gas could influence the gastric sensitivity and anxiety-like behavior of the brain-stomach axis regulated anxiety-like gastric hypersensitivity in FD rat model.
