Experiment Analysis of Antineutrophil Cytoplasmic Antibodies(ANCA)-associated Vasculitis Combined with Pulmonary Fibrosis
10.3870/j.issn.1672-0741.2017.06.013
- VernacularTitle:伴肺纤维化的MPO阳性ANCA相关性血管炎的临床研究
- Author:
Botao YIN
1
;
Bintao SU
;
Yanling YUE
Author Information
1. 华中科技大学同济医学院附属同济医院检验科
- Keywords:
antineutrophil cytoplasmic antibodies-associated vasculitis;
pulmoary fibrosis;
M PO;
thrombin
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2017;46(6):680-682,691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features of antineutrophil cytoplasmic antibodies-associated vasculitis com-bined with pulmonary fibrosis and the relationship of laboratory results.Methods Totally,33 patients with antineutrophil cyto-plasmic antibodies-associated vasculitis were divided into pulmonary fibrosis group(group A)and non-pulmonary fibrosis group (group B).Fourteen patients with connective tissue diseases-related pulmonary fibrosis served as disease control group,and 12 healthy people as normal control group.The levels of ANCA,plasma creatinine,high-sensitivity C-reactive protein,fibrinogen and D-dimer were detected.Results The creatinine level was significantly higher in group B than in disease control group and normal control group.The creatinine level was higher in group A than in disease control group and normal control group,with-out significant differences.The levels of FIB,D-D,and hsCRP were significantly higher in the group A,group B and disease con-trol group(all P< 0.05).In the group A,MPO expression was positively associated with FIB concentration(r= 0.64,P<0.05).Conclusion In pulmonary fibrosis disease,early detection of ANCA has clinical value in the diagnosis of AASV.And the higher concentration of M PO may hint thrombus formation.
