Advances in molecular mechanism of Sestrin function
- VernacularTitle:Sestrin功能的分子机制研究进展
- Author:
Xi HU
1
;
Wei HAN
Author Information
1. 哈尔滨医科大学附属第一医院心血管内科
- Keywords:
Sestrin;
ROS;
mTORC1;
leucine
- From:
Basic & Clinical Medicine
2018;38(1):98-102
- CountryChina
- Language:Chinese
-
Abstract:
Excessive accumulation of reactive oxygen species ( ROS) and Chronic activation of mechanistic target of rapamycin ( mTOR) complex 1 ( mTORC1) is associated pathologies .Sestrin is a versatile anti-aging protein .Sestrin as a Prx Reductase or as a Peroxidase ,which reduce ROS .Sestrin can upregulate autophagy and upregulate Nrf 2 and its antioxidant targets,which inhibit ROS.Sestrin bind to GATOR2, releasing GATOR1, and thereby promote the RagA/B-inhibiting activity .On the another hand activating AMPK which promote phosphorylation of TSC 2, and thereby inhibit Rheb.Sestrin inhibit mTORC1 through its inhibition of RagA/B and Rheb.Concentration of leucine can change conformation of Sestrin ,and thereby change its regulation of mTORC 1.
