The emm genotype of group A streptococcus isolated from clinical infected children,Beijing
10.3969/j.issn.1673-4130.2017.24.004
- VernacularTitle:北京地区儿童A组链球菌感染临床分离株的emm分型研究
- Author:
Yimeng LIU
1
;
Peng YANG
;
Shuangsheng WU
;
Yang PAN
;
Guilan LU
;
Daitao ZHANG
;
Weixian SHI
;
Quanyi WANG
;
Xiaomin PENG
Author Information
1. 北京市疾病预防控制中心/北京市预防医学研究中心
- Keywords:
group A streptococcus;
the emm gene;
scarlet fever;
children
- From:
International Journal of Laboratory Medicine
2017;38(24):3368-3370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the genetic distribution of group A streptococcus progeny(GAS)isolated from children with re-spiratory tract infection in Beijing in 2015.Methods The throat swabs were collected from children with clinical diagnosis of scarlet fever and pharyngeal infection during May to July,2015.16 pediatric outpatient departments or pediatric emergency department of hospitals located in 16 districts of Beijing were enrolled in this study.PCR amplification and gene sequencing were employed.The encoding mature M protein gene(emm)distribution in different condition was compared and analyzed.Results A total of 247 GAS were isolated,including 73(29.6%,73/247)isolates from cases with scarlet fever and 174(70.4%,174/247)isolates from cases with pharyngeal infection.Among all isolates,six genotypes of emm were identified,including emm12(53.4%,132/247),emm1(44. 1%,109/247)and others(emm22,emm75,emm131 and emm241,2.5%,6/247).The significant difference of emm distribution with age was observed in this study:emm1 isolates were dominant in children aged 6-12,whereas emm12 isolates were dominant in chil-dren aged 1-5(P<0.05).While the emm distribution showed no significant difference in groups with different location,gender,and disease pattern(P>0.05).Conclusion Emm1 and emm12 were the circulating genotype of GAS in Beijing children,2015.Moreo-ver,the difference of distribution between emm1 and emm12 was proved in this study.
