The effect of the timing of ERCP treatment option on the respiratory burst and levels of inflammatory cytokines of patients with acute obstructive suppurative cholangitis
10.3969/j.issn.1673-4130.2017.24.006
- VernacularTitle:ERCP治疗时机的选择对AOSC患者呼吸爆发及炎性因子水平的影响
- Author:
Qi ZOU
1
;
Jie CHEN
;
Chunsheng LI
;
Maohua FENG
Author Information
1. 上海市浦东医院普外科
- Keywords:
endoscopic retrograde cholangiopancreatography;
acute obstructive suppurative cholangitis;
respiratory burst and inflammatory factors
- From:
International Journal of Laboratory Medicine
2017;38(24):3374-3376
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the timing of endoscopic retrograde cholangiopancreatography(ERCP)treat-ment option on the respiratory burst and inflammatory factor level for acute obstructive suppurative cholangitis(AOSC)patients. Methods A total of 98 patients with AOSC who were treated in our hospital from January 2013 to June 2016 were retrospectively analyzed.The patients were divided into A group and B group according to the time of ERCP operation.42 cases in A group were received ERCP within 6 h after admission.56 cases in B group were received ERCP in 6-24 h after admission.,The serum levels of inflammatory cytokines were compared between the two groups before and after treatment.The apoptosis rate and respiratory burst rate of peripheral hematoma were compared between the two groups before and after treatment.The complications and death rate of the patients in the two groups were recorded.Results After treatment,the levels of TNF-α and IL-6 in the A group were signifi-cantly lower than those in the B group and the IL-10 level was significantly higher in the B group(P<0.05).After treatment,the rate of neutrophil apoptosis in the A group was significantly higher than that in the B group(P<0.05),and the respiratory burst level in the A group was significantly lower than that in the B group(P<0.05).The incidence number of complications and death in patients in group A was significantly lower than that in group B(P< 0.05).Conclusion ERCP treatment for patients with AOSC should be performed as early as possible and as soon as possible.Early ERCP treatment is safe and effective and can alleviate the inflammatory reaction of patients,improve the survival rate of patients,and is worthy of clinical promotion.
