CT texture analysis in differential diagnosis of clear-cell and non clear-cell renal cell carcinomas

VernacularTitle:定量CT纹理分析鉴别诊断透明细胞型与非透明细胞型肾癌
Author: Hailong ZHOU ¹ ; Gumuyang ZHANG ; Bing SHI ; Hao SUN ; Zhengyu JIN
Author Information

1. 中国医学科学院北京协和医学院北京协和医院放射科
Keywords: Carcinoma,renal cell; Tomography,X-ray computed; Texture analysis
From: Chinese Journal of Medical Imaging Technology 2017;33(12):1768-1773
CountryChina
Language:Chinese
Abstract: Objective To explore the value of CT texture analysis (CTTA) in differential diagnosis of non clear-cell renal cell carcinoma (non-ccRCC) and clear-cell renal cell carcinoma (ccRCC).Methods A total of 100 ccRCC and 27 nonccRCC lesions were retrospectively analyzed.CTTA was performed on multiphasic CT images by using TexRAD software,and texture features were compared between ccRCC and non-ccRCC.Results Compared with ccRCC,the mean and standard deviation,entropy as well as the mean of positive pixels (MPP) were significantly lower,while kurtosis was higher in non-ccRCC lesions on enhanced CT images (P＜0.001).No significant difference was observed in skewness between nonccRCC and ccRCC (P＞0.05).MPP at coarse texture scale on corticomedullary images identified non-ccRCC from ccRCC with an AUC of 0.92±0.04,the sensitivity was 0.85,specificity was 0.93 and accuracy was 0.87.Conclusion There are significant differences in CTTA parameters between non-ccRCC and ccRCC.CTTA has clinical value in differential diagnosis of non-ccRCC and ccRCC.