A system review on efficacy and safety of Shuxuetong Injection in treatment of acute cerebral infarction
10.7501/j.issn.1674-6376.2017.10.027
- VernacularTitle:疏血通注射液治疗急性脑梗死临床疗效和安全性的系统评价
- Author:
Jie LI
1
;
jun He CHEN
;
sen Wei DONG
;
yi Zhi SUN
;
gui Bao CHONG
Author Information
1. 哈励逊国际和平医院药学部
- Keywords:
Shuxuetong Injection;
Ginkgo biloba extract injection;
Yinxing Damo Injection;
Shuxuening Injection;
acute cerebral infarction;
evidence based research
- From:
Drug Evaluation Research
2017;40(10):1488-1494
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using Ginkgo biloba extract injection as control drug,to systematically review the efficacy and safety of Shuxuetong Injection in the treatment of acute cerebral infarction.Methods Database including PubMed,Medline,CNKI,VIP and WanFang Data were searched to collect randomized controlled trials (RCTs) about Shuxuetong Injection versus G.biloba extract injection in the treatment of acute cerebral infarction from database setup time to July of 2016.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies.The meta-analysis was conducted by RevMan 5.2 software.Results Total of 11 RCTs,1 338 patients were included.Meta-analysis showed that Shuxuetong Injection was significantly better than G.biloba extract injection in clinical total effective rate [RR =1.17,95％CI(1.11,1.23),P ＜ 0.01],reducing neurological deficit score [MD =-4.46,95％CI (-6.07,-3.25),P ＜ 0.01] and improving life ability score [MD =13.98,95％CI (11.30,16.65),P ＜ 0.01],there was no serious adverse reaction in both groups.Conclusion Current evidence shows that Shuxuetong Injection is effective and safe in the treatment of acute cerebral infarction better than G.biloba extract injection.
