Advances in the relation between myeloid derived suppressor cells and digestive system tumors
10.3760/cma.j.issn.1673-9752.2017.12.018
- VernacularTitle:髓样抑制细胞与消化系统肿瘤关系的研究进展
- Author:
Yingbin HUANG
1
;
Qiang TAI
;
Xingyuan JIAO
Author Information
1. 中山大学附属第一医院器官移植中心
- Keywords:
Digestive system neoplasms;
Myeloid derived suppressor cells;
Immunodepression;
Target
- From:
Chinese Journal of Digestive Surgery
2017;16(12):1260-1264
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid derived suppressor cell (MDSC) is a kind of myogenic stem cells that are induced by tumor-derived cytokines.MDSCs not only have their own immunosuppressive effects,but also can mediate the immunosuppressive effects of T lymphocytes through different mechanisms.Recent studies have shown that MDSCs involved in tumor immune escape,immune tolerance as well as other pathological processes,and played an important role in promoting the generation and development of tumors.The advances of the generation,immunosuppressive effects of MDSCs and their relation with digestive system tumors were summarized in this paper,which would provide evidences for the clinical use of MDSCs in treating digestive system tumors.
