Analgesic and anti-inflammatory effects of total alkaloid in Stephania kwangsiensis in vivo
10.7501/j.issn.1674-6376.2017.10.011
- VernacularTitle:广西地不容总生物碱体内抗炎镇痛作用研究
- Author:
lan Yu LUO
1
;
zhen Zeng LIAO
;
qin Lu LIAO
;
jun Liu MAO
;
wen Dong LI
Author Information
1. 桂林医学院附属医院
- Keywords:
Stephania kwangsiensis H.S.Lo;
total alkaloid;
anti-inflammation;
analgesia effect
- From:
Drug Evaluation Research
2017;40(10):1424-1427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the analgesic and anti-inflammatory effects in vivo of the total alkaloids in Stephania kwangsiensis (TARS).Methods Mice were respectively ig with high,middle,and low doses of TARS.The analgesic effects of TARS were evaluated by the formaldehyde induced pain method and tail-immersion response induced by hot water in mice,and anti-inflammatory effects were observed by cotton ball granuloma,egg white induced paw swelling method in mice.Results TARS could significantly inhibit formaldehyde induced pain in mice,reduce the hind licking times,extend tail withdrawal time induced by hot water,obviously reduced the formation of granulomatous in mice;Inhibited egg white induced paw swelling.Conclusion TARS has significant analgesic and anti-inflammatory effect.
