Clinical effect of Bosentan combined with Vardenafil on postoperative pulmonary hypertension associated with congenital heart and its influence on function of vascular endothelium
10.7501/j.issn.1674-6376.2017.10.018
- VernacularTitle:波生坦联合伐地那非治疗先天性心脏病术后肺动脉高压的临床疗效及对血管内皮功能的影响
- Author:
Lin GUO
1
;
Juan LI
Author Information
1. 郑州市第七人民医院重症医学科
- Keywords:
bosentan;
vardenafil;
congenital heart disease;
postoperative pulmonary hypertension
- From:
Drug Evaluation Research
2017;40(10):1453-1456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of bosentan combined with vardenafil on postoperative pulmonary hypertension associated with congenital heart and its influence on function of vascular endothelium.Methods 80 congenital heart disease patients with postoperative pulmonary hypertension,who were treated in our hospital from November,2011 to December,2015 were enrolled in the present study.They were randomly divided into observation group and control group,with each group of 40 cases.Both group received conventional therapy of oxygen and dieresis.The clinical effect,clinical symptom improvement,cardiac function were compared between the two groups.Results The clinical effect of control group was 80.0％ (32/40),which was significantly lower than that of observation group (90.0％,P ＜ 0.05).The sPAP,mPAP in both group were significantly decreased,and the Qp/Qs level was obviously increased (P ＜ 0.05);Borg score and NYHAFC score as well as the level of VEGF were largely decreased,and those of observation group were significantly lower than control group (P ＜ 0.05).In the terms of adverse reactions,there was no statistical difference between the two groups.Conclusion Bosentan combined with vardenafil was effective on postoperative pulmonary hypertension associated with congenital heart,which can significantly improve the clinical symptoms of patients with dyspnea,improve the cardiac function,worthy of clinical promotion.
