Efficacy and safety of reduced glutathione in the treatment of uremic patients with anemia
10.7501/j.issn.1674-6376.2017.10.021
- VernacularTitle:还原型谷胱甘肽联合重组人促红素治疗尿毒症贫血患者的有效性与安全性
- Author:
hua Jing ZHANG
1
;
an Chang WANG
;
jie Xiao HEI
Author Information
1. 郑州市第七人民医院肾内科
- Keywords:
Reduced glutathione;
uremia;
anemia;
renal function;
safety
- From:
Drug Evaluation Research
2017;40(10):1464-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effectiveness and safety of reduced glutathione in the treatment of uremic patients with anemia.Methods From January 2014 to May 2016,84 uremic patients with anemia in our hospital for treatment were selected as the research object and were equally divided into the observation group and control group with 42 patients in each group accorded to the random draw envelope principle.The control group was treated with hemodialysis and oral administration of erythropoietin therapy,the observation group was received the reduced glutathione treatment based on the control group,all patients were observed for 12 weeks.Results There were no serious complications in the two groups.The total effective rate of the observation group and the control group were 97.6％ and 85.7％ respectively.The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05).The serum UA values in observation group and the control group after treatment were significantly lower than that before treatment,the serum Ccr value were significantly higher than before treatment (P ＜ 0.05),At the same time after treatment,the serum UA and Ccr values in the observation group compared with the control group were statistical significance difference (P ＜ 0.05).The RBC and Hb in the observation group after treatment were (3.38 ± 0.34)×1012/L and (94.55 ± 4.92) g/L,and the control group were (2.56 ± 0.38)×1012/L and (73.24 ± 5.39) g/L respectively that were significantly higher than before treatment (P ＜ 0.05),and the observation group were significantly higher than those in control group (P ＜ 0.05).Conclusion Reduced glutathione in the treatment of uremic anemia can improve renal function and anemia status,improve the therapeutic efficacy,its better safety,and has a good value of application and promotion.
