Curative effect and safety of L-carnitine combined with alprostadil for patients with diabetic nephropathy
10.7501/j.issn.1674-6376.2017.10.025
- VernacularTitle:左卡尼汀联合前列地尔治疗糖尿病肾病的临床疗效及其安全性
- Author:
ru Xiao WANG
1
;
lan Xiu ZHOU
;
hong Hui MA
Author Information
1. 内蒙古师范大学医院药剂科
- Keywords:
L-carnitine;
alprostadil;
diabetic nephropathy;
blood glucose;
renal function;
curative effect
- From:
Drug Evaluation Research
2017;40(10):1481-1484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect and safety of L-carnitine combined with alprostadil for patients with diabetic nephropathy.Methods 102 patients with diabetic nephropathy were enrolled in hospital of Inner Mongolia normal university from August 2013 to December 2016,of which patients divided into two groups randomly,control group (n =50) accepted alprostadil treatment,and combined group (n =52) adopted L-camitine based on the patients in control group.The blood glucose and renal functions were detected respectively after treatment.And the curative effect was evaluated and compared between two groups;The adverse reactions were recorded and analyzed in the period of treatment.Results After treatment,the FBP,2 h BG,24 h uPro,BUN,Scr and β2-MG of patients in two groups were decreased significantly (P ＜ 0.05),and the change of combined group was higher than those control group significantly (P ＜ 0.05).After treatment,the total efficiency of combined group was higher than that patients in control group (P ＜ 0.05).The incidence of adverse reactions of control group in the period of treatment was 20.0％ (10/50),and combined group was 5.8％ (3/52),and which difference from two groups was no significance.Conclusions L-carnitine combined with alprostadil for patients with diabetic nephropathy deserved popularization in clinic,and which not only possessed remarkable curative effect,but also well controlled the blood glucose level,improved the renal function,decreased the incidence of adverse reactions certainly.
