Clinical efficacy of patients with breast cancer treated with breast-conserving therapy and modified radical mastectomy in China
10.3760/cma.j.issn.1673-4203.2017.09.008
- VernacularTitle:保乳术与改良根治术治疗中国早期乳腺癌患者临床疗效的系统评价
- Author:
Dongwei FAN
1
;
Xuanhe LI
;
Changyang YAO
;
Chensong ZHANG
;
Tingjing YAO
Author Information
1. 蚌埠医学院第一附属医院肿瘤外科
- Keywords:
Breast neoplasms;
Early diagnosis;
Mastectomy,modified radical;
Meta-analysis;
Breast conserving surgery
- From:
International Journal of Surgery
2017;44(9):603-606,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of breast conserving surgery and modified radical mastectomy on the clinical efficacy of patients with early breast cancer.Methods CNKI,Chinese Journal Full-text Database (CJFD),China Biology Medicine Disc (CBMdisc),China Dissertation Database (Chinese Dissertation Database,CDDB) google academic and other databases were comprehensive searched.And then the search time was limited to between January 1,2015 and September 1,2017.Key words can be locked for breast conserving surgery,improved surgery for breast surgery,case-control studies,etc.,and then meet the conditions of the literature into the study,for a retrospective analysis.The authors reviewed the literature independently,extracted data and evaluated the risk of bias,and used Review Manager 5.3 software for systematic analysis.Results A total of 1 093 patients with early breast cancer were enrolled in the study.The Meta-analysis showed:there was a significant difference in operation time between the two groups(MD =-30.71,95％ CI:-31.96--29.46,P ＜ 0.01);there was a significant difference in intraoperative blood loss between the two groups(MD =-53.30,95％ CI:-55.38--51.22,P ＜ 0.01);there was a significant difference in postoperative hospital stay (MD =-5.66,95％CI:-7.17--5.17,P ＜0.01) and the incidence of complications (OR =0.30,95％ CI:0.19-0.47,P ＜ 0.01)compared with modified radical mastectomy in early breast cancer patients.There was no significant difference between the two groups in the postoperative recurrence and metastasis (OR =0.78,95％ CI:0.54-1.13,P =0.19).Conclusions In the choice of surgical methods,breast-conserving therapy is better than modified radical surgery,and postoperative recurrence and metastasis rate has no significant difference.
