Role of TRAIL pathway and NKG2D pathway in double negative T cell cell anti-tumor
10.3760/cma.j.issn.1673-4203.2017.09.020
- VernacularTitle:TRAIL和NKG2D通路在双阴性T细胞抗肿瘤中的作用
- Author:
Pibo HU
1
;
Jiong CHEN
Author Information
1. 安徽医科大学附属省立医院普外科
- Keywords:
Immunity;
Pancreatic neoplasms;
DNT cell;
TRAIL;
NKG2D
- From:
International Journal of Surgery
2017;44(9):645-648
- CountryChina
- Language:Chinese
-
Abstract:
Double negative T cell is a rare type of cells that regulates immune responses in a way that is unique.In the process of adoptive immunotherapy,it gradually becomes a hot spot,because of its obvious anti-tumor effect.However,the mechanism by which DNT cell kills tumor cell is not clear.Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) and natural-killer group 2,member D (NKG2D) pathway is a more important part of its killing mechanism,and NKG2D receptor can also regulate the production of soluble TRAIL,making the two channels to establish a certain link.In this paper,the effect of Double negative T cell and the mechanism of TRAIL and NKG2D pathway in DNT cell's anticancer were described.
